Medical Wellness at Solace
Last updated May 2026
Cellular energy, DNA repair, cognitive clarity, and healthy aging — delivered as high-dose intramuscular injections for maximum bioavailability. Prescribed by Dr. Flávio, DNP, AACC.
What Is NAD+?
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every living cell. It is the substrate for cellular energy production (ATP synthesis via the mitochondrial electron transport chain), the required co-factor for DNA repair enzymes (PARPs), and the activator of sirtuins — the protein family most associated with longevity, stress resistance, and healthy aging. Without adequate NAD+, your cells cannot produce energy efficiently, cannot repair DNA damage promptly, and cannot maintain the biological processes that keep you feeling and functioning at your best.
The problem: NAD+ levels decline by approximately 40–60% between age 20 and age 60. This decline correlates with the clinical picture most adults experience as they age: fatigue that rest doesn’t fix, cognitive fog, slower recovery, declining metabolic rate, and a generalized sense that something is off. Restoring NAD+ doesn’t just address symptoms — it restores the cellular capacity that drives every system in your body.
Research reference: Rajman, Chwalek & Sinclair (2018) — Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence, Cell Metabolism, NCBI
Benefits of NAD+ Injections
NAD+ is the rate-limiting substrate for mitochondrial ATP production. Restoring optimal levels directly improves cellular energy output — reducing the fatigue that no amount of sleep seems to fix.
PARP enzymes that repair daily DNA damage require NAD+ as their substrate. Adequate NAD+ means faster, more complete repair — reducing the cellular damage accumulation associated with aging and cancer risk.
The brain is among the most energy-demanding organs in the body. NAD+ supports neuronal mitochondrial function, BDNF production, and the sirtuin pathways associated with memory, focus, and neuroprotection.
Sirtuins (SIRT1–7) are the longevity proteins activated by NAD+. They regulate inflammation, gene expression, circadian rhythm, and stress resistance. Optimal NAD+ is required for their function at any age.
Injections vs. Oral Supplements
The supplement market is filled with NAD+ precursors: NMN, NR, niacinamide. These oral compounds must be absorbed through the gut, converted through multiple metabolic steps, and then transported to cells — with significant losses at every stage. Bioavailability studies show that oral NAD+ precursors achieve only a fraction of the plasma concentrations achievable through direct injection.
At Solace, Dr. Flávio prescribes intramuscular NAD+ injections, which deliver the molecule directly into the bloodstream for immediate cellular uptake. Most patients report a noticeable improvement in energy, mental clarity, and mood within the first session. These are not placebo effects — they are the measurable consequence of rapidly restoring a critical cellular substrate that has been declining for decades.
For patients pursuing peptide therapy, hormone optimization, or comprehensive longevity protocols, NAD+ injections are frequently included as a foundational component. The combination of optimal mitochondrial function, hormonal balance, and targeted peptide signaling creates a biological environment that is significantly greater than the sum of its parts.
Comparing your options? Read our in-depth guide: NAD+ vs. IV Therapy Compared →
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NAD+ Injections FAQ
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme essential for cellular energy production, DNA repair, and activation of longevity proteins called sirtuins. NAD+ levels decline 40–60% between age 20 and 60, correlating with fatigue, cognitive decline, and slower recovery. Restoring NAD+ addresses these declines at the cellular level.
Oral NAD+ precursors (NMN, NR) must be absorbed through the gut and converted through multiple metabolic steps before reaching cells, with significant losses along the way. Injectable NAD+ enters the bloodstream directly, achieving plasma concentrations that oral forms cannot match. The clinical difference is noticeable — most patients report immediate effects from injection that oral supplements never produced.
Most patients report a brief flush of warmth or mild tingling during the injection, which passes quickly. Many describe an almost immediate sense of increased energy, mental clarity, and elevated mood. The injection takes only a few minutes and is administered by Dr. Flávio’s clinical team at Solace in Fort Myers.
Protocol frequency depends on your goals and baseline status. Most patients begin with a loading phase of 2–3 injections per week for 4 weeks, then transition to 1–2 injections per week for maintenance. Dr. Flávio designs your specific protocol based on your health history, labs, and response to initial treatments.
Yes — NAD+ is frequently included as a core component of comprehensive longevity and cognitive protocols at Solace. It is highly complementary to peptide therapy (particularly cognitive stacks and longevity protocols) and to our IV nutrient therapy, which ensures micronutrient cofactors that support NAD+ metabolism are fully replete.
The Science
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every cell of the body, essential to the reactions that convert food into ATP — the energy currency that powers every cellular function. Beyond energy production, NAD+ is a critical substrate for two classes of proteins with profound longevity implications: PARPs (poly ADP-ribose polymerases), which repair damaged DNA strands, and sirtuins, which regulate inflammation, metabolism, and the epigenetic marks that control how genes are expressed.
The problem is that NAD+ levels decline significantly with age — by approximately 50% between ages 40 and 60. This decline is not a passive consequence of aging; it may be one of its primary drivers. Research published in Cell Metabolism (Yoshino et al., 2021) demonstrated that restoring NAD+ levels in aging tissues restores mitochondrial function, reduces markers of cellular senescence, and improves insulin sensitivity. In practice, clients report more sustained energy, faster recovery from exercise, and improved mental clarity as the most consistent early benefits.
PARPs consume NAD+ to detect and repair DNA strand breaks. As we accumulate thousands of DNA damage events daily, without adequate NAD+, repair capacity drops — accelerating cellular aging and cancer risk. NAD+ repletion supports the repair systems that maintain genomic integrity.
Sirtuins (SIRT1–7) are longevity proteins that regulate metabolism, inflammation, and stress resistance — but only when NAD+ is available. SIRT1 reduces inflammatory NF-κB signaling. SIRT3 maintains mitochondrial health. SIRT6 regulates telomere length. All depend on NAD+ as their fuel.
Neurons are among the most energy-demanding cells in the body. Declining NAD+ impairs mitochondrial ATP production in brain cells, contributing to brain fog, poor memory, and cognitive decline. Restoring NAD+ levels supports neuronal energy supply and the DNA repair mechanisms that protect neurons from cumulative damage.
Conveniently located at 12545 New Brittany Blvd, Fort Myers, FL, Solace Wellness Aesthetics serves clients from Fort Myers, Cape Coral, Estero, Bonita Springs, Naples, and throughout Southwest Florida. If you're searching for a medical spa near you in SWFL, we're minutes away.
Book a NAD+ consultation with Dr. Flávio at Solace Wellness Aesthetics in Fort Myers. Your protocol will be designed around your individual labs and wellness goals.